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KMID : 0378119860130010297
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Chungnam Medical Journal
1986 Volume.13 No. 1 p.297 ~ p.306
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The Responses of Catecholamines, Cortisol, and Growth hormone to the insulin induced hypohlycemia in normal man
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Abstract
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To characterize the hormonal responses to hypoglycemia in normal man, plasma catecholamines, serum cortisol, growth hormone, glucose, blood pressure and pulse rate were measured in insulin induced hypoglcemic states. The blood samples were taken before and 15,30,60,90,120 min after i. v. injection of 0.1 U/B. W.kg regular insulin in 16 health volunteers after a 12-hours overnight fast.
The results were as follows :
1. The basal serum glucose level was 74.4±8.0mg/dl(M±SD) which was decreased to 34.1±5.2mg/dl at 30 min after insulin injection, returned to 84.7±10.5 at 120 min after insulin injection.
2. The basal plasma norepinephrine level was 121.3±42.5pg/ml and the no was no significant change with insulin injection. (P>0.05)
On the other hand, the basal Plasma epinephrine level was 43.8±14.7 pg/ml.
A 5 fold increase in epinephrine to 214.4±4.7.4 pg/ml was observed 30 min after insulin injection. (p<0.05)
3. The basal serum cortisol level was 10.9±2.1 pg/dl which was increased significantly to 16.4±4.1 pg/dl(p<0.01) at 60 min after insulin injection.
4. The basal serum growth hormone level was 0.5±0.1 ng/dl. A 45-fold increase in growth hormone to 24.5±5.6 ng/dl (P<0.005) was observed 60 min after insulin injection.
5. The blood pressure levels remained unchanged and pulse rate showed mean increase to 10/min at 30 min after insulin.
The results of this study indicate that epinephrine plays a major role in the metabolic response to insulin-induced hypoglycemia in normal man, growth hormone and cortisol may well function to argument the early hyperglycemic effect of epinephrine.
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